Basic information of Nfe2l2 :
| Official Symbol of Gene | Nfe2l2 |
| Species | Mus musculus |
| Entrez Gene ID | 18024 |
| Official Full Name | nuclear factor, erythroid derived 2, like 2 |
| Also known as | Nrf2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000015839 AllianceGenome:MGI:108420 |
| Map Location | 2 C3; 2 44.75 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | immunohistochemistry |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57Bl/6N mice |
| Sample Size | 62 animals |
Literature information of multiple sclerosis :
| Pubmed ID | 28921587 |
| Year | 2017 |
| Title | Dimethyl fumarate treatment after traumatic brain injury prevents depletion of antioxidative brain glutathione and confers neuroprotection |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Our findings suggest that DMF treatment confers neuroprotection after TBI via preservation of brain GSH levels rather than by modulating neuroinflammation. |
| Mechanism/Pathway | DMF-treated mice displayed less neurological deficits than vehicle-treated mice and reduced histopathological brain damage.At the same time, the TBI-evoked depletion of brain GSH was prevented by DMF treatment.However, Nrf2 target gene mRNA expression involved in antioxidant and detoxifying pathways was increased in both treatment groups at 4 dal. |
