Basic information of Ccl5 :
| Official Symbol of Gene | Ccl5 |
| Species | Mus musculus |
| Entrez Gene ID | 20304 |
| Official Full Name | chemokine (C-C motif) ligand 5 |
| Also known as | SISd; Scya5; RANTES; TCP228; MuRantes |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000035042 AllianceGenome:MGI:98262 |
| Map Location | 11 C; 11 50.66 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain ã€spinal cords |
| Sample Detail | predominant cell |
| Detected Method | Immunohistochemistry |
| Disease | acute encephalomyelitis and chronic demyelinating disease |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 9551936 |
| Year | 1998 |
| Title | Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | notably CRG-2, in the initiation and maintenance of an inflammatory response following infection with MHV, which is important in contributing to demyelination. |
| Mechanism/Pathway | regulation of chemokine expression contributes to the initiation and maintenance of the chronic inflammatory response that is observed in MHV-infected mice. Production of chemokines, notably CRG-2, by resident astrocytes may aid in attracting T cells and microglia/macrophage to areas in which MHV is present, and these cells participate in the demyelination process through, as of yet, undiscovered mechanisms |
