Basic information of Mbp :
| Official Symbol of Gene | Mbp |
| Species | Mus musculus |
| Entrez Gene ID | 17196 |
| Official Full Name | myelin basic protein |
| Also known as | jve; mld; shi; Hmbpr; golli-mbp |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000041607 AllianceGenome:MGI:96925 |
| Map Location | 18 E3; 18 55.84 cM |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral bloodã€CSF |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | female Suffolk-Merino sheep |
| Sample Size | 10 serum and 4 CSF samples |
Literature information of multiple sclerosis :
| Pubmed ID | 9014312 |
| Year | 1996 |
| Title | Mimicry of a 21.5 kJIa myelin basic protein peptide by a Maedi Visna virus polymerase peptide does not contribute to the pathogenesis of encephalitis in sheep |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Since the MVV peptide was not recognised by antibodies or T lymphocytes from MVV-infected and encephalic sheep, it was concluded that epitope mimicry of this 2 1.5 kDa MBP peptide by the similar MVV pal peptide was not contributing to the immunopathogensis of Visna. The slight antibody response to MBP and the MBP peptide can be attributed to by-stander effects of the immunopathology of MVV-induced encephalitis. |
| Mechanism/Pathway | Weise and Carnegie found a region of sequence similarity between the pal gene of the Maedi Visna virus (MVV), which induces demyelinating encephalitis in sheep, and myelin basic protein (MBP), which is known to induce experimental allergic encephalitis (EAE) in laboratory animals |
