Basic information of S1pr3 :
| Official Symbol of Gene | S1pr3 |
| Species | Mus musculus |
| Entrez Gene ID | 13610 |
| Official Full Name | sphingosine-1-phosphate receptor 3 |
| Also known as | Edg3; Lpb3; S1p3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000067586 AllianceGenome:MGI:1339365 |
| Map Location | 13; 13 A5 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | astrocyte |
| Detected Method | Western blotting |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57BL/6 wild-type and homozygous S1P3 KO mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 28577576 |
| Year | 2017 |
| Title | Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | S1P3, through its ability to activate RhoA and its upregulation in astrocytes, plays a unique role in inducing inflammatory responses and should be considered as a potentially important therapeutic target for CNS disease progression |
| Mechanism/Pathway | S1P induces expression of all of these genes through coupling to the Gα12/13 proteins which activate RhoA |
