Basic information of S100b :
| Official Symbol of Gene | S100b |
| Species | Mus musculus |
| Entrez Gene ID | 20203 |
| Official Full Name | S100 protein, beta polypeptide, neural |
| Also known as | Bpb |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000033208 AllianceGenome:MGI:98217 |
| Map Location | 10 C1; 10 38.76 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | cerebellar |
| Detected Method | Western blot |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 33100970 |
| Year | 2020 |
| Title | S100B Impairs Oligodendrogenesis and Myelin Repair Following Demyelination Through RAGE Engagement |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | our electron microscopy data show that inhibition of the S100B–RAGE axis prevents axonal damage and myelin loss, in parallel with enhanced functional remyelination, as observed by the presence of thinner myelin sheaths when compared with Control. Overall, our data implicate the S100B–RAGE axis in the extent of myelin and neuronal damage, as well as in the inflammatory response that follows |
| Mechanism/Pathway | we confirmed that LPC-induced demyelination increased S100B and RAGE expression, while RAGE antagonist FPS-ZM1 markedly reduced their content and altered RAGE cellular localization |
