Basic information of Hmox1 :
| Official Symbol of Gene | Hmox1 |
| Species | Mus musculus |
| Entrez Gene ID | 15368 |
| Official Full Name | heme oxygenase 1 |
| Also known as | HO1; HO-1; Hmox; Hemox; Hsp32; D8Wsu38e |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000005413 AllianceGenome:MGI:96163 |
| Map Location | 8 35.59 cM; 8 C1 |
Sample information of multiple sclerosis:
| Detected Sample | bone marrow (BM) |
| Sample Detail | Bone marrow derived macrophages (BMDM) |
| Detected Method | Western blot |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57BL/6 (WT) and LysM-Cre mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 33191652 |
| Year | 2020 |
| Title | Monomethylfumarate Ameliorates Murine Macrophage Activation Syndrome in Both Heme Oxygenase 1-dependent and -independent Manners |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | TLR9 induced IL-10 is under the control of HO-1 activity both in vitro and in vivo. Therapeutic enhancement of the HO-1/IL-10 axis in a murine model was able to significantly ameliorate MAS disease activity. These results suggest targeting HO-1 may be viable as a MAS therapeutic target, and DMF and MmF should be considered in investigations of MAS therapy |
| Mechanism/Pathway | HO-1 is required for the majority of TLR9 induced IL-10 |
