Basic information of FOXP3 :
| Official Symbol of Gene | FOXP3 |
| Species | Homo sapiens |
| Entrez Gene ID | 50943 |
| Official Full Name | forkhead box P3 |
| Also known as | JM2; AIID; IPEX; PIDX; XPID; DIETER |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000049768 MIM:300292; AllianceGenome:HGNC:6106 |
| Map Location | Xp11.23 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | CD4+ Foxp3+ cells |
| Detected Method | Immunohistochemistry |
| Disease | MSã€primary immune thrombocytopenia |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 15 with multiple sclerosisã€16 with primary immune thrombocytopenia(primary ITP)and 19 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 32317002 |
| Year | 2020 |
| Title | A unique thymus-derived regulatory T cell subset associated with systemic lupus erythematosus |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | CD4+ Foxp3+ T cells were increased in SLE patients compared with organ-specific autoimmune disease controls or healthy controls. Circulating CD4+ Foxp3+ T cells were correlated with the disease activity of SLE. The increased CD4+ Foxp3+ T cells in active SLE patients were mainly derived from thymus-derived Treg (tTreg) cells, as determined by a demethylated TSDR status, and represented a unique phenotype, upregulated expression of CD49d, CD161, and IL-17A, with immunosuppressive ability comparable to that of healthy controls. Finally, CD4+ Foxp3+ IL-17A+ cells were infiltrated into the renal biopsy specimens of patients with active lupus nephritis. |
| Mechanism/Pathway | A unique tTreg subset with dichotomic immunoregulatory and T helper 17 phenotypes is increased in the circulation of SLE patients and may be involved in the pathogenic process of SLE |
