Basic information of Il1 :

Official Symbol of Gene	Il1
Species	Mus musculus
Entrez Gene ID	111343
Official Full Name	interleukin 1 complex
Also known as	Il-1
Gene Type	other
dbXrefs	MGI:MGI:96536
Map Location	chromosome: 2

Sample information of multiple sclerosis:

Detected Sample	brain
Sample Detail	N/A
Detected Method	Immunohistochemical
Disease	inflammatory response, cell death, and edema development
Disease subtype	N/A
Population	male Sprague–Dawley rats
Sample Size	n = 5–6 mice group

Literature information of multiple sclerosis :

Pubmed ID	10616089
Year	2000
Title	108 Intracerebral administration of interleukin-1B and induction of inflammation, apoptosis, and vasogenic edema

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Intracerebral inflammation, death of intrinsic CNS cells, and vasogenic edema can be mediated by IL-1β, and TNF can cause vasogenic edema. Suppression of these cytokines in the clinical setting may improve outcome
Mechanism/Pathway	cell death occurred via the apoptotic pathway. The TNF did not induce inflammation or DNA fragmentation within the analyzed time period. Both IL-1 and TNFcaused vasogenic edema, as measured by specific gravity and albumin staining. The edematous effect of TNF persisted 72 hours after injection , whereas the IL-1β–treated animals had normalized by that time.