Basic information of CCL5 :

Official Symbol of Gene	CCL5
Species	Homo sapiens
Entrez Gene ID	6352
Official Full Name	C-C motif chemokine ligand 5
Also known as	SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000271503 MIM:187011; AllianceGenome:HGNC:10632
Map Location	17q12

Sample information of multiple sclerosis:

Detected Sample	brain
Sample Detail	N/A
Detected Method	ELISA
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	11389171
Year	2001
Title	Glatiramer acetate inhibition of tumor necrosis factor-a-induced RANTES expression and release from U-251 MG human astrocytic cells

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	glatiramer acetate may exert its therapeutic effect in MS partially through inhibiting NF-kB activation and chemokine production
Mechanism/Pathway	our electrophoretic mobility shift assays of nuclear extracts from TNF-a-treated cells reveal an increase in DNA-binding activity specic for the nuclear factor-kappa B (NF-kB) binding site, in the 50 -ˉanking promoter region of the human RANTES gene, and that this increase in NF-kB binding activity is prevented by pretreatment with glatiramer acetate or the NF-kB inhibitors.