Basic information of CCL5 :

Official Symbol of Gene	CCL5
Species	Homo sapiens
Entrez Gene ID	6352
Official Full Name	C-C motif chemokine ligand 5
Also known as	SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000271503 MIM:187011; AllianceGenome:HGNC:10632
Map Location	17q12

Sample information of multiple sclerosis:

Detected Sample	brain
Sample Detail	astroglioma cell
Detected Method	ELISA
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	11408956
Year	2001
Title	Comparison of RANTES chemokine induction by Thl cytokines in human astroglial cell lines

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	U-105MG cells treated with TNF-a and IL-l alone or in combination markedly induced increases in the rate of transcription of the RANTES chemokine gene
Mechanism/Pathway	IFN-y alone had little effect on RANTES production in both U-373MG and U-105MG cells, while TNF-a or IL-I alone had differential effects in the two cell lines. Low levels of RANTES chemokine were detected in culture supernatants from U-373MG cells. By contrast, TNF-a or IL-l dramatically increased RANTES secretion in U-105MG cells. Interestingly, different combination treatments of cells with the three cytokines synergistically induced RANTES release from both U373MG and U-105MG cells.