Basic information of Nos2 :
| Official Symbol of Gene | Nos2 |
| Species | Mus musculus |
| Entrez Gene ID | 18126 |
| Official Full Name | nitric oxide synthase 2, inducible |
| Also known as | iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000020826 AllianceGenome:MGI:97361 |
| Map Location | 11 B5; 11 46.74 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | microglial cells |
| Detected Method | Immunoblot analysis |
| Disease | MS |
| Disease subtype | N/A |
| Population | Purified murine |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 14505805 |
| Year | 2003 |
| Title | Involvement of protein kinase Cd and extracellular signal-regulated kinase-2 in the suppression of microglial inducible nitric oxide synthase expression by N-[3,4-dimethoxycinnamoyl]-anthranilic acid (tranilast) |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In summary, we show that TNL inhibits LPS-induced activation of iNOS by inhibiting the activation of PKCd and ERK-2, thus possibly affecting post-translational modification of iNOS mRNA. Our result may have further implications for the use of TNL as a novel therapeutic agent in neurological disorders associated with activation of microglia and increased NO release, including multiple sclerosis |
| Mechanism/Pathway | PKCd and ERK-2 |
