Basic information of Rag1 :
| Official Symbol of Gene | Rag1 |
| Species | Mus musculus |
| Entrez Gene ID | 19373 |
| Official Full Name | recombination activating 1 |
| Also known as | Rag-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000061311 AllianceGenome:MGI:97848 |
| Map Location | 2 E2; 2 53.88 cM |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | CD4+ã€CD8+ |
| Detected Method | immunohistochemistry |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 16885234 |
| Year | 2006 |
| Title | Immune Cells Contribute to Myelin Degeneration and Axonopathic Changes in Mice Overexpressing Proteolipid Protein in Oligodendrocytes |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | These findings provide strong evidence that a primary glial damage can cause secondary immune reactions of pathological significance as it has been suggested for some forms of multiple sclerosis and other leukodystrophies. |
| Mechanism/Pathway | Overexpression of the major myelin protein of the CNS, proteolipid protein (PLP), leads to late-onset degeneration of myelin and pathological changes in axons |
