Basic information of Apoe :
| Official Symbol of Gene | Apoe |
| Species | Mus musculus |
| Entrez Gene ID | 11816 |
| Official Full Name | apolipoprotein E |
| Also known as | Apo-E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000002985 AllianceGenome:MGI:88057 |
| Map Location | 7 A3; 7 9.94 cM |
Sample information of multiple sclerosis:
| Detected Sample | aortic valve and sinuses of Valsalva |
| Sample Detail | N/A |
| Detected Method | Western Blot |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57BL/6J |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 17483449 |
| Year | 2007 |
| Title | Deletion of the phosphoinositide 3-kinase p110β gene attenuates murine atherosclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In marked contrast to the embryonic lethality seen in mice lacking class Ia PI3-kinase, germ-line deletion of p110r results in mice that exhibit normal viability, longevity, and fertility, with relatively well tolerated defects in innate immune and inflammatory responses that may play a role in diseases such as atherosclerosis and multiple sclerosis. Our results not only shed mechanistic light on inflammatory signaling during atherogenesis, but further identify p110r as a possible target for pharmacological intervention in the primary and secondary prevention of human atherosclerotic cardiovascular disease |
| Mechanism/Pathway | Inflammatory cell activation by chemokines requires intracellular signaling through phosphoinositide 3-kinase (PI3-kinase) and the PI3-kinase-dependent protein serine/threonine kinase Akt |
