Basic information of IL2 :

Official Symbol of Gene	IL2
Species	Homo sapiens
Entrez Gene ID	3558
Official Full Name	interleukin 2
Also known as	IL-2; TCGF; lymphokine
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000109471 MIM:147680; AllianceGenome:HGNC:6001
Map Location	4q27

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	Jurkat E6.1 (ATCC TIB152) T cells
Detected Method	Western blot
Disease	multiple sclerosis, psoriasis and type 1 diabetes
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	19104661
Year	2008
Title	Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	clofazimine is a promising immunomodulatory drug candidate for treating a variety of autoimmune disorders.
Mechanism/Pathway	Clofazimine was initially identified as an inhibitor of intracellular T cell receptor-mediated signaling leading to the transcriptional activation of human interleukin-2 gene in T cells from a screen of the Johns Hopkins Drug Library. A systematic mechanistic deconvolution revealed that clofazimine selectively blocked the Kv1.3 channel activity, perturbing the oscillation frequency of the calcium-release activated calcium channel, which in turn led to the inhibition of the calcineurin-NFAT signaling pathway.