Basic information of Csf1 :
| Official Symbol of Gene | Csf1 |
| Species | Mus musculus |
| Entrez Gene ID | 12977 |
| Official Full Name | colony stimulating factor 1 (macrophage) |
| Also known as | op; Csfm; MCSF; BAP025; Mhdabap25 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000014599 AllianceGenome:MGI:1339753 |
| Map Location | 3 F2.3; 3 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | Microglia |
| Detected Method | Immunohistochemistry |
| Disease | myelin disorders. |
| Disease subtype | N/A |
| Population | B6C3Fe-Csf1 op/J mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 19396881 |
| Year | 2016 |
| Title | Selective Reduction in Microglia Density and Function in the White Matter of Colony-stimulating factor-1–Deficient Mice |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | A similar decrease was seen at 7 months of age. Morphometric studies of spinal cord myelination showed that development of myelin was not affected in op/op mice. In response to a stab wound, the increase in the number of microglia/macrophages in op/op mice was significantly less pronounced than that in wild-type control. These findings demonstrate that this mutant is a valuable model in which to study roles of microglia/macrophages in the pathophysiology of myelin disorders |
| Mechanism/Pathway | The osteopetrotic (op/op) mouse has reduced numbers of cells of monocyte lineage as a result of an inactivating mutation in the colony stimulating factor-1 gene |
