Basic information of OLIG2 :

Official Symbol of Gene	OLIG2
Species	Homo sapiens
Entrez Gene ID	10215
Official Full Name	oligodendrocyte transcription factor 2
Also known as	BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000205927 MIM:606386; AllianceGenome:HGNC:9398
Map Location	21q22.11

Sample information of multiple sclerosis:

Detected Sample	brain
Sample Detail	oligodendrocyte precursor cells (OPCs)
Detected Method	Immunocytochemical characterization
Disease	multiple sclerosis or traumas such as spinal cord injury
Disease subtype	N/A
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	20538536
Year	2010
Title	Production and isolation of NG2+ oligodendrocyte precursors from human embryonic stem cells in defined serum-free medium

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	OPCs were differentiated as spheres in defined serum-free medium supplemented with recombinant human growth factors. A broad gene expression analysis revealed that this OPC population expressed Olig1/2, Sox10, PDGFR, Nkx2.2, Nkx6.2, oligodendrocyte-myelin glycoprotein, myelin basic protein (MBP), and proteolipid protein (PLP). According to quantitative RTPCR analyses addition of ciliary neurotrophic factor (CNTF) upregulated the Olig2 mRNA levels in the OPC population. According to the flow cytometry analyses the OPC population was N90% NG2-positive, N80% PDGFR-positive, and N60% CD44-positive, and further matured into O4- (45%) and GalC- (80%) positive oligodendrocyte populations when cultured on top of human extracellular matrix proteins, which were used instead of Matrigel. In addition, OPCs matured into myelin-forming cells when cocultured with neuronal cells.
Mechanism/Pathway	OPC population expressed Olig1/2, Sox10, PDGFR, Nkx2.2, Nkx6.2