Basic information of Il2 :
| Official Symbol of Gene | Il2 |
| Species | Mus musculus |
| Entrez Gene ID | 16183 |
| Official Full Name | interleukin 2 |
| Also known as | Il-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000027720 AllianceGenome:MGI:96548 |
| Map Location | 3 B; 3 18.3 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | hippocamp |
| Detected Method | Immunohistochemistry |
| Disease | neurodegenerative diseases (e.g., Alzheimer’s disease), neurodevelopmental disorder (e.g., autism, schizophrenia), and autoimmune diseases including multiple sclerosis |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 22933152 |
| Year | 2012 |
| Title | Interleukin-2 and the Brain: Dissecting Central Versus Peripheral Contributions Using Unique Mouse Models |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Models such as the congenic IL-2 knockout mice bred on immunode fi cient backgrounds coupled with immune reconstitution strategies can be valuable to test novel hypotheses such as our postulation that changes in the brain’s endogenous neuroimmunological milieu that occur with the loss of brain IL-2 gene expression may be involved in initiating CNS autoimmunity. Thus, further research using this approach may help to delineate further the complexity of IL-2 biology in the brain and immune system |
| Mechanism/Pathway | It is noteworthy that IL-2 has been shown to be one of the most potent modulators of acetylcholine (ACh) release from rat hippocampal slices |
