Basic information of NT5E :
| Official Symbol of Gene | NT5E |
| Species | Homo sapiens |
| Entrez Gene ID | 4907 |
| Official Full Name | 5'-nucleotidase ecto |
| Also known as | NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000135318 MIM:129190; AllianceGenome:HGNC:8021 |
| Map Location | 6q14.3 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | CD8+ T cells |
| Detected Method | ELISA |
| Disease | HIVinfectedã€MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 124 human subjects were recruited for our studies (S1 Table) including: 1) 26 HIV-infected but antiretroviral therapy (ART)-naive individuals; 2) 63 HIV-infected individuals on ART (ART); and 3) 13 Long-term non-progressors (LTNPs) |
Literature information of multiple sclerosis :
| Pubmed ID | 35325005 |
| Year | 2022 |
| Title | Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8+ T cells of HIV-infected individuals |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | ATP-mediated downregulation of CD73 mainly occurs via its receptor, P2X1/P2RX1. Our results may in part explain why HIV-infected individuals have reduced risk of developing MS considering the role of CD73 for efficient T cell entry into the central nervous system |
| Mechanism/Pathway | elevated levels of ATP in the plasma of HIV-infected individuals upregulates the expression of miRNA30b-e in T cells in vitro. In turn, inhibition of miRNAs (30b, 30c and 30e) resulted in significant upregulation of CD73 mRNA in CD8+ T cells. Therefore, we provide a novel mechanism for the downregulation of CD73 via ATP-induced upregulation of miRNA30b, 30c and 30e in HIV infection |
