Basic information of PTPRC :

Official Symbol of Gene	PTPRC
Species	Homo sapiens
Entrez Gene ID	5788
Official Full Name	protein tyrosine phosphatase receptor type C
Also known as	LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000081237 MIM:151460; AllianceGenome:HGNC:9666
Map Location	1q31.3-q32.1

Sample information of multiple sclerosis:

Detected Sample	CSF
Sample Detail	T cells
Detected Method	Immunofluorescence labelling
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	50 patients in acute relapse of clinically definite multiple sclerosis (MS), 8 patients with primary progressive MS, 26 patients with inflammatory neurological disease (IND), 33 patients with non-inflammatory neurological disease (NIND) and 31 healthy subjects

Literature information of multiple sclerosis :

Pubmed ID	7853024
Year	1994
Title	T cell distribution in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	These results suggest that V61 + and V62 + y6 T cells with altered CD45 expression are reduced in CSF of patients with established MS. This finding may be related to sequestration or apoptosis of y8 T cells within active MS lesions.
Mechanism/Pathway	Patterns of lymphocyte recirculation in man appear to be closely related to cell surface expression of the CD45RA and CD45RO isoforms of the common leucocyte antigen CD45