Basic information of Trav6-3 :
| Official Symbol of Gene | Trav6-3 |
| Species | Mus musculus |
| Entrez Gene ID | 328483 |
| Official Full Name | T cell receptor alpha variable 6-3 |
| Also known as | Gm4; TCR; Gm193; Gm13948 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000094220 IMGT/GENE-DB:TRAV6-3; AllianceGenome:MGI:3649610 |
| Map Location | 14; 14 C2 |
Sample information of multiple sclerosis:
| Detected Sample | splenocytes |
| Sample Detail | CD41 KJ1261 cells |
| Detected Method | immunizations |
| Disease | EAE |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 10799918 |
| Year | 2000 |
| Title | Repertoire Requirements of CD41 T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | we conclude that CD41 T regulatory cells do not express canonical TCRs and that the altered signaling properties brought about by coexpression of two TCRs are not sufficient for the generation of regulatory T cells. Instead, our results indicate that regulatory T cells belong to a population displaying wide TCR diversity, but in which TCR specificity is central to their protective function |
| Mechanism/Pathway | as myelin basic protein-specific/OVA-specific recombinase activating gene-12/2 double TCR transgenic mice still developed experimental autoimmune encephalomyelitis spontaneously even after immunization with OVA |
