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Basic information of Cxcl10 :

Official Symbol of Gene Cxcl10
Species Rattus norvegicus
Entrez Gene ID 245920
Official Full Name C-X-C motif chemokine ligand 10
Also known as IP-10; Scyb10
Gene Type protein coding
dbXrefs Ensembl:ENSRNOG00000022256AllianceGenome:RGD:620209
Map Location 14p22

Sample information of multiple sclerosis:

Detected Sample Peripheral blood
Sample Detail N/A
Detected Method Western blot
Disease EAE
Disease subtype N/A
Population SJL mice, and C57BL/6 mice
Sample Size n = 5–6 mice group

Literature information of multiple sclerosis :

Pubmed ID 12023393
Year 2002
Title Plasmid DNA Encoding IFN-r Inducible Protein 10 Redirects Antigen-Specific T Cell Polarization and Suppresses Experimental Autoimmune Encephalomyelitis

Results of multiple sclerosis :

Expression up-regulation
Risk type Disease risk
Result This demonstrates not only the pivotal role of a chemokine in T cell polarization and function but also its potential implications for plasmid DNA gene therapy
Mechanism/Pathway IFN-r inducible protein 10 (IP-10) is a CXC chemokine that stimulates the directional migration of activated T cells, particularly Th1 cells