Basic information of ERVW-1 :
| Official Symbol of Gene | ERVW-1 |
| Species | Homo sapiens |
| Entrez Gene ID | 30816 |
| Official Full Name | endogenous retrovirus group W member 1, envelope |
| Also known as | ENV; ENVW; HERVW; ERVWE1; HERV7Q; HERV-7q; HERVWENV; HERV-W-ENV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000242950 MIM:604659; AllianceGenome:HGNC:13525 |
| Map Location | 7q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | microglial cells |
| Detected Method | Immunohistology |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 15804956 |
| Year | 2005 |
| Title | Human endogenous retrovirus (HERV)-W ENV and GAG proteins: Physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | This is compatible with a pathophysiological role in MS, but also illustrates the ambivalence of such HERV antigens, which can be expressed in cell-specific patterns, under physiological or pathological conditions |
| Mechanism/Pathway | converging results from three groups confirm that GAG and ENV proteins encoded by the HERV-W multicopy gene family are expressed in cells of the central nervous system under normal conditions |
