Basic information of PTPRC :

Official Symbol of Gene	PTPRC
Species	Homo sapiens
Entrez Gene ID	5788
Official Full Name	protein tyrosine phosphatase receptor type C
Also known as	LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; IMD105
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000081237 MIM:151460; AllianceGenome:HGNC:9666
Map Location	1q31.3-q32.1

Sample information of multiple sclerosis:

Detected Sample	venous blood
Sample Detail	T cell
Detected Method	Immunoprecipitation and immunoblotting
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	3 patients/5 control

Literature information of multiple sclerosis :

Pubmed ID	16393978
Year	2006
Title	The 77C3G Mutation in the Human CD45 (PTPRC) Gene Leads to Increased Intensity of TCR Signaling in T Cell Lines from Healthy Individuals and Patients with Multiple Sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	These data suggest that 77C3G may act as a risk factor for certain diseases by increasing the intensity of TCR signaling
Mechanism/Pathway	Mutant T cell lines contained a more active pool of p56lck tyrosine kinase and responded with increased phosphorylation of Zap70 and TCR- and an enhanced Ca2+ flux to TCR/CD3 stimulation