Basic information of Gm4736 :
| Official Symbol of Gene | Gm4736 |
| Species | Mus musculus |
| Entrez Gene ID | 100502592 |
| Official Full Name | predicted gene 4736 |
| Also known as | Mp4; Mp6; EG114600 |
| Gene Type | protein coding |
| dbXrefs | AllianceGenome:MGI:3647826 |
| Map Location | 6; 6 G1 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | ELISPOT assays and ELISPOT image analysis |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n =8 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 16781782 |
| Year | 2006 |
| Title | MBP-PLP fusion protein-induced EAE in C57BL/6 miceB |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In summary, the MP4-induced EAE of B6 mice bears many features seen in different neuroantigen/mouse strain combinations, all of which are hallmarks of MS. In particular the dependence on CD8+ T and B cells, the multi-determinant specificity of the CD4+ T cell response, and the rapid onset of EAE are distinct features that distinguish MP4-induced EAE from the MOG:35 – 55triggered disease of B6 mice and possibly from PLP:178– 191 peptide-induced EAE. New models will help adopt the rapidly growing array of genetically-manipulated mice for mechanism-oriented studies of immunological as well as degenerative and reparative processes as they pertain to MS. |
| Mechanism/Pathway | MBP-PLP fusion protein (MP4)-induced EAE for C57BL/6 mice. B cell- and CD8+ T cell-dependence, as well as multi-determinant recognition are among the unique features of this demyelinating EAE |
