Basic information of CD200 :

Official Symbol of Gene	CD200
Species	Homo sapiens
Entrez Gene ID	4345
Official Full Name	CD200 molecule
Also known as	MRC; MOX1; MOX2; OX-2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000091972 MIM:155970; AllianceGenome:HGNC:7203
Map Location	3q13.2

Sample information of multiple sclerosis:

Detected Sample	brain
Sample Detail	macrophages (microglia)
Detected Method	Immunohistochemistry
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	19 MS cases containing white matter lesions and white matter tissue of 10 control

Literature information of multiple sclerosis :

Pubmed ID	17879969
Year	2007
Title	Downregulation of Macrophage Inhibitory Molecules in Multiple Sclerosis Lesions

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	These data suggest that diminished immune inhibition via decreased CD200 and CD47 expression contributes to a disturbed equilibrium in macrophage and microglia activation in MS lesions. Furthermore, this may result in a proinflammatory predisposition in the area surrounding chronic active lesions, thereby contributing to axonal injury, demyelination, and possible lesion expansion
Mechanism/Pathway	The membrane glycoproteins CD200 and CD47, highly expressed on neurons, are mediators of macrophage inhibition via their receptors CD200R and signal-regulatory protein, respectively, on myeloid cells. We determined the expression pattern of immune inhibitory molecules in relation to genes involved in macrophage activation and MS lesion pathology