Basic information of Foxp3 :
| Official Symbol of Gene | Foxp3 |
| Species | Mus musculus |
| Entrez Gene ID | 20371 |
| Official Full Name | forkhead box P3 |
| Also known as | sf; JM2; scurfin |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000039521 AllianceGenome:MGI:1891436 |
| Map Location | X A1.1; X 3.41 cM |
Sample information of multiple sclerosis:
| Detected Sample | lymph nodes |
| Sample Detail | T cells |
| Detected Method | Immunofluorescence |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 (B6) mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 18490732 |
| Year | 2008 |
| Title | Latency-Associated Peptide Identifies a Novel CD4+CD25+Regulatory T Cell Subset with TGFβ-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Our work helps elucidate the ambiguity concerning the role of TGFβ in CD4+CD25+ Treg-mediated suppression and indicates that LAP is an authentic marker able to identify a TGFβ-expressing CD4+CD25+ Treg subset |
| Mechanism/Pathway | CD4+CD25+LAP+ cells suppress myelin oligodendrocyte glycoprotein-specific immune responses by inducing Foxp3 and by inhibiting IL-17 production. |
