Basic information of MBP :
| Official Symbol of Gene | MBP |
| Species | Homo sapiens |
| Entrez Gene ID | 4155 |
| Official Full Name | myelin basic protein |
| Also known as | Note: MBP (Gene ID: 4155) and MBL2 (Gene ID: 4153) share the MBP symbol/alias in common. MBP is a widely used alternative name for mannose binding lectin 2 (MBL2), which can be confused with the official symbol for MBP (myelin basic protein, GeneID 4155). [01 Jun 2018] |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000197971MIM:159430;AllianceGenome:HGNC:6925 |
| Map Location | 18q23 |
Sample information of multiple sclerosis:
| Detected Sample | Brain and Spinal |
| Sample Detail | N/A |
| Detected Method | Immunostaining |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 19726693 |
| Year | 2009 |
| Title | Inflammatory Proprotein Convertase-Matrix Metalloproteinase Proteolytic Pathway in Antigen-presenting Cells as a Step to Autoimmune Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | These data suggest that MMP-25 plays an important role in MS pathology and that MMP-25, especially because of its restricted cell/tissue expression pattern and cell surface/lipid raft localization, is a promising drug target in MS |
| Mechanism/Pathway | We have discovered biochemical evidence suggesting the presence of the inflammatory proteolytic pathway leading to MS. The pathway involves the self-activated furin and PC2 proprotein convertases and membrane type-6 MMP (MT6-MMP/MMP25) that is activated by furin/PC2. These events are followed by MMP-25 proteolysis of the Golli-MBP isoforms in the immune system cells and stimulation of the specific autoimmune T cell clones |
