Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
Sample information of multiple sclerosis:
| Detected Sample | peripheral lymphoid organs |
| Sample Detail | Lymph node |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | n=3 |
Literature information of multiple sclerosis :
| Pubmed ID | 24463315 |
| Year | 2014 |
| Title | Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells |
Results of multiple sclerosis :
| Expression | down-regulated |
| Risk type | disease risk |
| Result | DRG2 overexpression decreases the TH17 population and expression levels of proinflammatory cytokines in peripheral blood cells. |
| Mechanism/Pathway | Autoantigen-specific TH1 and TH17 lineages have been shown to mediate EAE. |
