Basic information of Gjc2 :
| Official Symbol of Gene | Gjc2 |
| Species | Mus musculus |
| Entrez Gene ID | 118454 |
| Official Full Name | gap junction protein, gamma 2 |
| Also known as | Cx47; Cxno; Gja12; B230382L12Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000043448 AllianceGenome:MGI:2153060 |
| Map Location | 11 B1.3; 11 37.05 cM |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | immunoassay |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 31932428 |
| Year | 2019 |
| Title | Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | These findings suggest that oligodendroglia-specific Cx47 ablation induces severe inflammation upon autoimmune demyelination, underscoring a critical role for Cx47 in regulating neuroinflammation. |
| Mechanism/Pathway | CXCR3-CCR6+CD4+ and IL17+IFNγ-CD4+ helper T (Th) 17 cells isolated from spinal cord and brain tissues were significantly increased in Cx47 icKO mice compared with Cx47 fl/fl mice, while MOG35-55-specific proliferation and proinflammatory cytokine production of splenocytes were unaltered |
