Basic information of Mcu :
| Official Symbol of Gene | Mcu |
| Species | Mus musculus |
| Entrez Gene ID | 215999 |
| Official Full Name | mitochondrial calcium uniporter |
| Also known as | Gm64; C10orf42; Ccdc109a; 2010012O16Rik; D130073L02Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000009647 AllianceGenome:MGI:3026965 |
| Map Location | 10; 10 B4 |
Sample information of multiple sclerosis:
| Detected Sample | spinal cord |
| Sample Detail | N/A |
| Detected Method | Western blotting |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 32745471 |
| Year | 2020 |
| Title | Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | These findings suggest that MCU inhibition contributes to axonal damage that drives MS progression |
| Mechanism/Pathway | cytoskeletal damage, fragmented mitochondria and large autophagosomes were seen in EAE/Thy1-MCU Def axons |
