Basic information of Nos2 :
| Official Symbol of Gene | Nos2 |
| Species | Mus musculus |
| Entrez Gene ID | 18126 |
| Official Full Name | nitric oxide synthase 2, inducible |
| Also known as | iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000020826AllianceGenome:MGI:97361 |
| Map Location | 11 B5; 11 46.74 cM |
Sample information of multiple sclerosis:
| Detected Sample | medulla spinalis |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Adult female Lewis rats |
| Sample Size | 18cases |
Literature information of multiple sclerosis :
| Pubmed ID | 26616879 |
| Year | 2015 |
| Title | Pertussis toxin promotes relapsing–remitting experimental autoimmune encephalomyelitis in Lewis rats |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Increase in inflammation, the extent of myelin lesions and oxidative stress were also observed in EAE animals treated with PT. |
| Mechanism/Pathway | Injection of myelin antigens stimulates the animal's immune system for proliferating and expansion of immune cells activated against the antigens. These reactive cells pass the blood–brain barrier and face the CNS parenchyma where they make inflammatory products and cytokines and destroy the myelin. They also activate microglia presented in CNS and produce factors which recruit more inflammatory components and perpetuate inflammatory cascade. B cells and their antibodies enter CNS as well and plasma cells produce some antibodies in CNS. Antibody-mediated destruction takes part in inflammatory demyelination and axonal damage |
