Basic information of Ccl2 :
| Official Symbol of Gene | Ccl2 |
| Species | Mus musculus |
| Entrez Gene ID | 20296 |
| Official Full Name | chemokine (C-C motif) ligand 2 |
| Also known as | JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000035385 AllianceGenome:MGI:98259 |
| Map Location | 11 B5; 11 49.82 cM |
Sample information of multiple sclerosis:
| Detected Sample | peripheral lymphoid organs |
| Sample Detail | Lymph node and Spleen |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | n=3 |
Literature information of multiple sclerosis :
| Pubmed ID | 24463315 |
| Year | 2014 |
| Title | Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells |
Results of multiple sclerosis :
| Expression | down-regulated |
| Risk type | disease risk |
| Result | DRG2 overexpression decreases the TH17 population and expression levels of proinflammatory cytokines in peripheral blood cells. |
| Mechanism/Pathway | Autoantigen-specific TH1 and TH17 lineages have been shown to mediate EAE. |
