Basic information of EAAT-2 :

Official Symbol of Gene	EAAT-2
Species	Mus musculus
Entrez Gene ID	20511
Official Full Name	solute carrier family 1 (glial high affinity glutamate transporter), member 2
Also known as	GLT1; Eaat2; GLT-1; MGLT1; 1700091C19Rik; 2900019G14Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000005089 AllianceGenome:MGI:101931
Map Location	2 E2; 2 54.13 cM

Sample information of multiple sclerosis:

Detected Sample	spinal cord
Sample Detail	N/A
Detected Method	Western blot
Disease	EAE
Disease subtype	N/A
Population	C57BL/6 mice
Sample Size	CFA n=3; EAE n=3

Literature information of multiple sclerosis :

Pubmed ID	23291347
Year	2013
Title	Changes in nociceptive sensitivity and object recognition in experimental autoimmune encephalomyelitis (EAE)

Results of multiple sclerosis :

Expression	down-regulated
Risk type	disease risk
Result	There is a significant decrease in the levels of spinal EAAT-2 mice with EAE when compared to CFA. All samples are taken at disease onset.
Mechanism/Pathway	Interestingly, IL-6 is also known to be a major factor triggering the downregulation of EAAT-2.