Basic information of Il17a :
| Official Symbol of Gene | Il17a |
| Species | Mus musculus |
| Entrez Gene ID | 16171 |
| Official Full Name | interleukin 17A |
| Also known as | Il17; Ctla8; IL-17; Ctla-8; IL-17A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000025929 AllianceGenome:MGI:107364 |
| Map Location | 1; 1 A4 |
Sample information of multiple sclerosis:
| Detected Sample | Serum |
| Sample Detail | spleen CD4+ T cells |
| Detected Method | flow cytometry |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 and CD1 mice |
| Sample Size | seven mice per condition |
Literature information of multiple sclerosis :
| Pubmed ID | 24868560 |
| Year | 2014 |
| Title | Regulatory lymphocytes are key factors in MHC-independent resistance to EAE |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result |
Only C57BL/6 mice that developed EAE after immunization with MOG35 |
| Mechanism/Pathway | Upregulation of B and, to a lesser extent, of Treg, is closely associated with MHCindependent resistance to MOG-induced EAE in CD1 mice and with the abrogation of both Th1 and Th17 responses. |
