Basic information of Il12a :
| Official Symbol of Gene | Il12a |
| Species | Mus musculus |
| Entrez Gene ID | 16159 |
| Official Full Name | interleukin 12a |
| Also known as | p35; Ll12a; Il-12a; IL-12p35 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000027776 AllianceGenome:MGI:96539 |
| Map Location | 3 E1; 3 31.92 cM |
Sample information of multiple sclerosis:
| Detected Sample | Serum |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | B10 mice |
| Sample Size | three per group |
Literature information of multiple sclerosis :
| Pubmed ID | 12663683 |
| Year | 2003 |
| Title | HLA class II transgenic mice authenticate restriction of myelin oligodendrocyte glycoprotein-specific immune response implicated in multiple sclerosis pathogenesis |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | Cytokine analysis revealed an increase in pro-inˉammatory (IFN g, IL-12 and IL-6) and antiinˉammatory (IL-10) cytokines. |
| Mechanism/Pathway | In most forms of EAE, the Th1 cells or Th1 cytokines promote disease, while Th2 cells or cytokines down-regulate disease. |
