Basic information of Tgfb1 :
| Official Symbol of Gene | Tgfb1 |
| Species | Mus musculus |
| Entrez Gene ID | 21803 |
| Official Full Name | transforming growth factor, beta 1 |
| Also known as | Tgfb; Tgfb-1; TGFbeta1; TGF-beta1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000002603 AllianceGenome:MGI:98725 |
| Map Location | 7 A3; 7 13.98 cM |
Sample information of multiple sclerosis:
| Detected Sample | lymph node |
| Sample Detail | lymph node cells |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6J mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 17372022 |
| Year | 2007 |
| Title | TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26 |
Results of multiple sclerosis :
| Expression | down-regulated |
| Risk type | Disease risk |
| Result | Notably, the production of the immunosuppressive cytokine TGF-1b was significantly diminished in culture supernatants of both unstimulated and MOG p35–55-stimulated lymph node cells obtained from MOG-primed CD26-/- animals in comparison with cells from CD26-/-wild-type mice. |
| Mechanism/Pathway | this lack of intrinsic TGF-β1 release may cause exacerbation of EAE. |
