Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
Sample information of multiple sclerosis:
| Detected Sample | lymph node |
| Sample Detail | T cell |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6J mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 17372022 |
| Year | 2007 |
| Title | TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26 |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | Levels of IFN-g, IL-2, and TNF-a in these cultures were measured by specific ELISA. |
| Mechanism/Pathway | As these cytokines are associated with the encephalitogenic potency of myelin Ag-specific T cells, we conclude that enhanced Th1 cell reactivity in response to MOG is part of the underlying mechanism causing enhanced disease scores in CD26-/- mice. |
