Basic information of DNMT1 :
| Official Symbol of Gene | DNMT1 |
| Species | Homo sapiens |
| Entrez Gene ID | 1786 |
| Official Full Name | DNA methyltransferase 1 |
| Also known as | AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130816 MIM:126375; AllianceGenome:HGNC:2976 |
| Map Location | 19p13.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | Western blot |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 40 subjects (not receiving disease modifying therapies) with definite MS and 40 healthy volunteers |
Literature information of multiple sclerosis :
| Pubmed ID | 24735979 |
| Year | 2014 |
| Title | TET2 gene expression and 5-hydroxymethylcytosine level in multiple sclerosis peripheral blood cells |
Results of multiple sclerosis :
| Expression | down-regulated |
| Risk type | Disease risk |
| Result | We show that TET2 and DNMT1 expression is significantly down-regulated in MS PBMCs and it is associated with aberrant methylation of their promoters. |
| Mechanism/Pathway | Furthermore, 5hmC is decreased in MS PBMCs, probably as a result of the diminished TET2 level. |
