Basic information of LILRA3 :
| Official Symbol of Gene | LILRA3 |
| Species | Homo sapiens |
| Entrez Gene ID | 11026 |
| Official Full Name | leukocyte immunoglobulin like receptor A3 |
| Also known as | HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4 |
| Gene Type | protein coding |
| dbXrefs | MIM:604818 |
| Map Location | 19q13.4 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | serum |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | RRMS,SPMS,PPMS |
| Population | North Americans of European descent |
| Sample Size | A total of 456 patients with MS and 99 unrelated healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26871720 |
| Year | 2016 |
| Title | Serum Leukocyte Immunoglobulin-Like Receptor A3 (LILRA3) Is Increased in Patients with Multiple Sclerosis and Is a Strong Independent Indicator of Disease Severity; 6.7kbp LILRA3 Gene Deletion Is Not Associated with Diseases Susceptibility |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | LILRA3 protein level was significantly increased in sera of patients with MS when compared with control subjects, particularly in more severe type primary progressive MS. |
| Mechanism/Pathway | Taken together our results indicate that LILRA3 is not a risk variant in MS susceptibility but is involved in modulating inflammation thereby contributing to the variability in disease severity and/or clinical outcomes. |
