Basic information of Ccl6 :
| Official Symbol of Gene | Ccl6 |
| Species | Mus musculus |
| Entrez Gene ID | 20305 |
| Official Full Name | chemokine (C-C motif) ligand 6 |
| Also known as | c10; MRP-1; Scya6 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000018927 AllianceGenome:MGI:98263 |
| Map Location | 11 C; 11 50.85 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | cerebellum and spinal cord |
| Detected Method | immunohistochemistry |
| Disease | EAE |
| Disease subtype | N/A |
| Population | GFAP-IL3 mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 10233856 |
| Year | 1999 |
| Title | C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | Notably, high expression of C10 and C10-related genes was found in the cerebellum and spinal cord of GFAP-IL3 mice with inflammatory demyelinating disease and in mice with experimental autoimmune encephalomyelitis. |
| Mechanism/Pathway | C10 is a prominent chemokine expressed in the central nervous system in experimental inflammatory demyelinating disease that, we show, also acts as a potent chemotactic factor for the migration of these leukocytes to the brain. |
