Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | T ceells |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | DR3.Aβ° mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 18490779 |
| Year | 2008 |
| Title | HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gamma |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | T cells from PLP91–110 peptide-immunized DR3.DQ6.Aβ° and DQ6.Aβ° mice produced high levels of IFN-g compared with DR3.Aβ° mice, while T cells from DR3.Aβ° produced increased levels of IL-6, IL-12, and TNF-γ. |
| Mechanism/Pathway | N/A |
