Basic information of Tet1 :
| Official Symbol of Gene | Tet1 |
| Species | Mus musculus |
| Entrez Gene ID | 52463 |
| Official Full Name | tet methylcytosine dioxygenase 1 |
| Also known as | LCX; Cxxc6; mKIAA1676; D10Ertd17e; 2510010B09Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000047146 AllianceGenome:MGI:1098693 |
| Map Location | 10 B4; 10 32.48 cM |
Sample information of multiple sclerosis:
| Detected Sample | SC tissue |
| Sample Detail | peripheral blood cells |
| Detected Method | Western Blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | N = 6–7 mouse samples. |
Literature information of multiple sclerosis :
| Pubmed ID | 30426768 |
| Year | 2018 |
| Title | DNA hydroxymethylation changes in response to spinal cord damage in a multiple sclerosis mouse model |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We found that Tet1 and Tet2 protein significantly decreased at day 28 after EAE induction. |
| Mechanism/Pathway | Therefore, the reduced expression of Tet1 and Tet2 protein represents an important cause of MS-induced myelin damage that leads to the decrease of DNA 5hmC in EAE-induced nontraumatic SC damage. |
