Basic information of Il2 :
| Official Symbol of Gene | Il2 |
| Species | Mus musculus |
| Entrez Gene ID | 16183 |
| Official Full Name | interleukin 2 |
| Also known as | Il-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000027720 AllianceGenome:MGI:96548 |
| Map Location | 3 B; 3 18.3 cM |
Sample information of multiple sclerosis:
| Detected Sample | the hind footpad and base of tail |
| Sample Detail | PLP139 –151-specific T cell lines |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | SJL/J mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 15749867 |
| Year | 2005 |
| Title | Amelioration of established experimental autoimmune encephalomyelitis by an MHC anchor-substituted variant of proteolipid protein 139-151 |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Thus, PLP139 –151-specific T cells have a dra matically reduced capacity to proliferate or secrete IL-2 following treatment with 145D, and there is an absence of deviation in cy tokine production. |
| Mechanism/Pathway | These data suggest that autoreactive T cells may be rendered anergic in vivo upon encountering less stable MHC variant peptides and thereby be less capable of mediating EAE. |
