Basic information of Il17a :
| Official Symbol of Gene | Il17a |
| Species | Mus musculus |
| Entrez Gene ID | 16171 |
| Official Full Name | interleukin 17A |
| Also known as | Il17; Ctla8; IL-17; Ctla-8; IL-17A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000025929 AllianceGenome:MGI:107364 |
| Map Location | 1; 1 A4 |
Sample information of multiple sclerosis:
| Detected Sample | CNS tissue |
| Sample Detail | CNS inflammatory cells |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | HLA-DR3.DQ8 transgenic mice |
| Sample Size | n=5 mice per group |
Literature information of multiple sclerosis :
| Pubmed ID | 28793252 |
| Year | 2017 |
| Title | Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | CNS inflammatory cells from P. histicola treated group had reduced levels of inflammatory cytokines IFN-γ and IL-17 as measured by ELISA (F) and flow cytometry (G and H) compared with the medium treated group. |
| Mechanism/Pathway | P. histicola challenge led to a decrease in pro inflammatory Th1 and Th17 cells, and increase in the frequencies of CD4+FoxP3+ regulatory T cells, tolerogenic dendritic cells, and suppressive macrophage. |
