Basic information of Lcn2 :
| Official Symbol of Gene | Lcn2 |
| Species | Mus musculus |
| Entrez Gene ID | 16819 |
| Official Full Name | lipocalin 2 |
| Also known as | NRL; 24p3; Sip24 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000026822 AllianceGenome:MGI:96757 |
| Map Location | 2 B; 2 22.09 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | mononuclear cells |
| Detected Method | Western blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | n=3 animals/group |
Literature information of multiple sclerosis :
| Pubmed ID | 22499213 |
| Year | 2012 |
| Title | Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | We show that Lcn2 is significantly upregulated in the spinal cord throughout EAE and is expressed predominantly by monocytes and reactive astrocytes. |
| Mechanism/Pathway | Lcn2 is a multi-functional protein that plays a role in glial activation, matrix metalloproteinase(MMP) stabilization, and cellular iron flux. |
