Basic information of Il1 :

Official Symbol of Gene	Il1
Species	Mus musculus
Entrez Gene ID	111343
Official Full Name	interleukin 1 complex
Also known as	Il-1
Gene Type	other
dbXrefs	N/A
Map Location	chromosome: 2

Sample information of multiple sclerosis:

Detected Sample	spinal cords
Sample Detail	N/A
Detected Method	ELISA
Disease	EAE
Disease subtype	N/A
Population	SJL/J mice
Sample Size	n=4 per group

Literature information of multiple sclerosis :

Pubmed ID	9637509
Year	1998
Title	The effect of gammadelta T cell depletion on cytokine gene expression in experimental allergic encephalomyelitis

Results of multiple sclerosis :

Expression	down-regulation
Risk type	Disease risk
Result	ELISA data confirmed the reduced levels of IL-1 and IL-6 at disease onset in GL3-treated animals, and pathologic analysis demonstrated a marked reduction in meningeal infiltrates at the same time point.
Mechanism/Pathway	we showed previously that depletion of γδT cells using the mAb GL3 immediately before disease onset, or during the chronic phase, significantly ameliorated clinical severity.