Basic information of Tsc22d3 :
| Official Symbol of Gene | Tsc22d3 |
| Species | Mus musculus |
| Entrez Gene ID | 14605 |
| Official Full Name | TSC22 domain family, member 3 |
| Also known as | DIP; Gilz; Dsip1; Tilz3; TSC-22R |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000031431 AllianceGenome:MGI:1196284 |
| Map Location | X; X F1 |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6J (H-2b ) female mice |
| Sample Size | n = 3–5/group |
Literature information of multiple sclerosis :
| Pubmed ID | 25114100 |
| Year | 2014 |
| Title | Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Endogenous regulator (GILZ) expression by splenic DCs isolated from EAE mice treated with HGF. |
| Mechanism/Pathway | In this study,we demonstrate that systemic HGF treatment ameliorates EAE through the development of tolerogenic dendritic cells (DCs) with high expression levels of glucocorticoid-induced leucine zipper (GILZ), a transcriptional repressor of gene expression and a key endogenous regulator of the inflammatory response. |
