Basic information of Pomc :
| Official Symbol of Gene | Pomc |
| Species | Rattus norvegicus |
| Entrez Gene ID | 24664 |
| Official Full Name | proopiomelanocortin |
| Also known as | Pomc1; Pomc2; alphaMSH |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000012686 AllianceGenome:RGD:3366 |
| Map Location | 6q14 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | serum |
| Detected Method | Western blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | DA rats |
| Sample Size | n = 6/group |
Literature information of multiple sclerosis :
| Pubmed ID | 34220419 |
| Year | 2021 |
| Title | The Function of the Hypothalamic-Pituitary-Adrenal Axis During Experimental Autoimmune Encephalomyelitis: Involvement of Oxidative Stress Mediators |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Our results reveal an upregulation of Pomc gene expression, followed by POMC and ACTH protein increase at the peak of the EAE in the pituitary. |
| Mechanism/Pathway | The increased gene and protein levels of POMC and ACTH in the pituitary lead to increased corticosterone levels. |
