Basic information of PLTP :

Official Symbol of Gene	PLTP
Species	Homo sapiens
Entrez Gene ID	5306
Official Full Name	phospholipid transfer protein
Also known as	BPIFE; HDLCQ9
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000100979 MIM:172425; AllianceGenome:HGNC:9093
Map Location	20q13.12

Sample information of multiple sclerosis:

Detected Sample	whole blood
Sample Detail	N/A
Detected Method	Western Blot Analysis
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	111 MS subjects / 45 controls

Literature information of multiple sclerosis :

Pubmed ID	26347820
Year	2015
Title	Elevated Phospholipid Transfer Protein in Subjects with Multiple Sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	We have identified the anomaly as the phospholipid transfer protein by western blot using antiphospholipid transfer antibodies. Activity assays showed that the phospholipid transfer activity was elevated in fasted plasma samples from subjects with MS compared to controls.
Mechanism/Pathway	Alterations in metabolic pathways in subjects with MS have been suggested before .These include abnormalities in the plasma proteins, reduced levels of lecithin cholesterol acyltransferase in the brain, alterations in plasma and cellular lipid profiles, and differences in the phospholipid content of normal myelin compared with myelin from subjects with MS.PLTP transfers phospholipids but lacks the ability to transfer either CE or TG.Both CETP and PLTP have been detected in plasma and cerebrospinal fluid (CSF) where they play important roles in maintaining lipid homeostasis.