Basic information of IL10 :

Official Symbol of Gene	IL10
Species	Homo sapiens
Entrez Gene ID	3586
Official Full Name	interleukin 10
Also known as	CSIF; TGIF; GVHDS; IL-10; IL10A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000136634 MIM:124092; AllianceGenome:HGNC:5962
Map Location	1q32.1

Sample information of multiple sclerosis:

Detected Sample	peripheral blood leukocytes
Sample Detail	N/A
Detected Method	ELISA
Disease	MS
Disease subtype	RRMS, SPMS
Population	Lithuania
Sample Size	26 patients with MS / 19 healthy subjects

Literature information of multiple sclerosis :

Pubmed ID	35741685
Year	2022
Title	IL-10 Gene Polymorphisms and IL-10 Serum Levels in Patients with Multiple Sclerosis in Lithuania

Results of multiple sclerosis :

Expression	No significance
Risk type	Disease risk
Result	No statistically significant differences were observed between two groups.
Mechanism/Pathway	IL-10 is an important cytokine regulator of the immune system, secreted mainly by macrophages and T lymphocytes.It is involved in the immune response to infectious and autoimmune diseases.IL-10 has an anti-inflammatory effect by reducing the production of immunoactive molecules (TNF-α, IFNγ, and IL-12) and inhibiting antigen-specific cytotoxic T cells.Since IL-10 may have an inflammatory function, it activates B cells and promotes autoantibody production.In the absence of IL-2, it inhibits T-cell apoptosis and promotes T-cell growth . It has been shown to increase the productivity of IL-10-producing cells.